Biomolecular spectroscopy & dynamics

We are an energetic group of analytical, physical, and biological chemists interested in developing and applying new spectroscopic approaches to understand the biophysics of proteins. By combining linear and advanced two-dimensional infrared techniques with methods of biochemistry and chemical biology for placing vibrational probe groups at specific sites, we map out the conformations and dynamics throughout proteins to evaluate their contribution to biological function. Our studies have focused on several systems with potential to reveal how protein heterogeneity and dynamics are involved in fundamental cellular processes, including metabolism, signaling, and photosynthesis. Check out our Research and Publications pages to learn more about our group!

The Thielges group is actively looking for post-doctoral scholars with interest in spectroscopy or biochemistry. Interested applicants should contact Dr. Megan Thielges at thielges@indiana.edu.


Indiana University Chemistry Department
800 E. Kirkwood Ave.
Bloomington, IN 47405